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Mohammad Razavi defended his Ph.D. thesis

News: Jun 22, 2020

Mohammad Razavi at CARe defended his doctoral thesis entitled “Identification of novel antibiotic resistance genes through the exploration of mobile genetic elements” on June 11th at 13:00.
An interested audience followed the event via Zoom. Chang-Jun Cha, Institute of Microbiomics and Center for Antibiotic Resistome, Chung-Ang University, Seoul, South Korea was the main opponent.

Chang-Jun Cha, Opponent

 

As can be asserted by the thesis title (and the articles, see below), Dr Razavi has employed new approaches to identify novel antibiotic resistance genes that are already present or have the potential to accumulate in pathogens. Through the exploration of bacterial DNA recovered from two polluted sites in India, Dr Razavi and co-workers could discover several novel antibiotic resistance genes, one already present in human pathogens.

 Polluted rivers

 

The discovery of the fourth novel mobile sulfonamide resistance genes (sul4) was reported in the first paper where they showed sul4 is already widespread in seven countries across Asia and Europe. In the second paper, a gene named gar, with a novel resistance mechanism against aminoglycoside antibiotics was discovered. The gar was already present in several clinical isolates collected from patients in Italy and China and also in food-borne pathogens in the USA, however, due to its unknown genomic features, gar had escaped discovery for many years. Moreover, the team could identify novel beta-lactamase genes (blaIDC), in new genetic context with increased potential to be transferred into and maintained in pathogens. In addition, in this thesis, insertion sequences as one of the important genetic elements in bacterial genomes responsible for the movements of antibiotic resistance genes were studied to facilitate the discovery of novel antibiotic resistance genes in the future. The acquired knowledge in this thesis could offer possibilities for early surveillance, actions to reduce transmission, gene-based diagnostics, and ultimately improved treatment of bacterial infections.

Dissertation via Zoom

 

Agnes Wold and Mohammad Razavi

 

Mohammad Razavi and Joakim Larsson (Supervisor)

 

 

 

 

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